Synchronized expressions of hepatic stellate cells and their transactivation and liver regeneration during liver injury in an animal model of cholestasis
FS Alatas, K Masumoto, T Matsuura… - Journal of Pediatric …, 2011 - Elsevier
BACKGROUND: There is much known about hepatic stellate cells (HSCs) during liver injury.
However, some aspects remain unclear, such as the natural expression levels of HSCs
during the days to weeks after liver injury. Does liver regeneration start the same time as the
injury process? METHODS: Fifty-four male Wistar rats aged 7 to 8 weeks, weighing 200 to
320 g each were subjected to bile duct ligation (BDL). After surgery, they were killed at
different times post-BDL. Collagen deposition was analyzed, and immunohistochemical …
However, some aspects remain unclear, such as the natural expression levels of HSCs
during the days to weeks after liver injury. Does liver regeneration start the same time as the
injury process? METHODS: Fifty-four male Wistar rats aged 7 to 8 weeks, weighing 200 to
320 g each were subjected to bile duct ligation (BDL). After surgery, they were killed at
different times post-BDL. Collagen deposition was analyzed, and immunohistochemical …