Role of transforming growth factor beta (TGFβ) in systemic autoimmunity

G Del Giudice, MK Crow - Lupus, 1993 - journals.sagepub.com
G Del Giudice, MK Crow
Lupus, 1993journals.sagepub.com
Transforming growth factor (TGFβ) is a multifunctional cytokine with proinflammatory as well
as immunosuppressive activities. A regulatory role for TGFβ has been suggested in
investigations of several experimental and spontaneous models of pathological
autoreactivity. It is suggested that many of the functional effects of TGFβ parallel the major
immune system abnormalities seen in SLE.
Transforming growth factor (TGFβ) is a multifunctional cytokine with proinflammatory as well as immunosuppressive activities. A regulatory role for TGFβ has been suggested in investigations of several experimental and spontaneous models of pathological autoreactivity. It is suggested that many of the functional effects of TGFβ parallel the major immune system abnormalities seen in SLE.
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