Genomic analyses of musashi1 downstream targets show a strong association with cancer-related processes
R de Sousa Abreu, PC Sanchez-Diaz, C Vogel… - Journal of biological …, 2009 - ASBMB
Musashi1 (Msi1) is a highly conserved RNA-binding protein with pivotal functions in stem
cell maintenance, nervous system development, and tumorigenesis. Despite its importance,
only three direct mRNA targets have been characterized so far: m-numb, CDKN1A, and c-
mos. Msi1 has been shown to affect their translation by binding to short elements located in
the 3′-untranslated region. To better understand Msi1 functions, we initially performed an
RIP-Chip analysis in HEK293T cells; this method consists of isolation of specific RNA …
cell maintenance, nervous system development, and tumorigenesis. Despite its importance,
only three direct mRNA targets have been characterized so far: m-numb, CDKN1A, and c-
mos. Msi1 has been shown to affect their translation by binding to short elements located in
the 3′-untranslated region. To better understand Msi1 functions, we initially performed an
RIP-Chip analysis in HEK293T cells; this method consists of isolation of specific RNA …
