[HTML][HTML] Identification of Murr1 as a regulator of the human δ epithelial sodium channel
W Biasio, T Chang, CJ McIntosh… - Journal of Biological …, 2004 - ASBMB
The human δ epithelial sodium channel (δENaC) subunit is related to the α-, β-, and γENaC
subunits that control salt homeostasis. δENaC forms an amiloride-sensitive Na+ channel
with the β and γ subunits. However, the in vivo function of δENaC is not known. To gain
insight into the function of δENaC, a yeast two-hybrid screen of a human brain cDNA library
was carried out using the C-and N-terminal domains of δENaC. A novel δENaC-interacting
protein called Murr1 (mouse U2af1-rs1 region) was isolated in the C-terminal domain …
subunits that control salt homeostasis. δENaC forms an amiloride-sensitive Na+ channel
with the β and γ subunits. However, the in vivo function of δENaC is not known. To gain
insight into the function of δENaC, a yeast two-hybrid screen of a human brain cDNA library
was carried out using the C-and N-terminal domains of δENaC. A novel δENaC-interacting
protein called Murr1 (mouse U2af1-rs1 region) was isolated in the C-terminal domain …