Context Neuroblastoma is diagnosed over a wide age range from birth through young
adulthood, and older age at diagnosis is associated with a decline in survivability. Objective
To identify genetic mutations that are associated with age at diagnosis in patients with
metastatic neuroblastoma. Design, Setting, and Patients Whole genome sequencing was
performed on DNA from diagnostic tumors and their matched germlines from 40 patients
with metastatic neuroblastoma obtained between 1987 and 2009. Age groups at diagnosis …