Derivation of HLA-B* 0702 transgenic mice: functional CTL repertoire and recognition of human B* 0702-restricted CTL epitopes
Transgenic mice expressing chimeric human leukocyte antigen (HLA)-B* 0702 and murine
H-2Kb class I molecules were evaluated as a model system to study the immunogenicity of
human cytotoxic T lymphocyte epitopes. Immunization of these mice with six known HLA-B*
0702–restricted cytotoxic T lymphocyte epitopes emulsified in incomplete Freund's adjuvant
induced significant immune responses specific for all six epitopes. A comparison of the
immune responses between HLA-B* 0702/Kb and HLA-A* 0201/Kb transgenic mice …
H-2Kb class I molecules were evaluated as a model system to study the immunogenicity of
human cytotoxic T lymphocyte epitopes. Immunization of these mice with six known HLA-B*
0702–restricted cytotoxic T lymphocyte epitopes emulsified in incomplete Freund's adjuvant
induced significant immune responses specific for all six epitopes. A comparison of the
immune responses between HLA-B* 0702/Kb and HLA-A* 0201/Kb transgenic mice …