[HTML][HTML] Down-regulation of Myc is essential for terminal erythroid maturation
Terminal differentiation of mammalian erythroid progenitors involves 4–5 cell divisions and
induction of many erythroid important genes followed by chromatin and nuclear
condensation and enucleation. The protein levels of c-Myc (Myc) are reduced dramatically
during late stage erythroid maturation, coinciding with cell cycle arrest in G 1 phase and
enucleation, suggesting possible roles for c-Myc in either or both of these processes. Here
we demonstrate that ectopic Myc expression affects terminal erythroid maturation in a dose …
induction of many erythroid important genes followed by chromatin and nuclear
condensation and enucleation. The protein levels of c-Myc (Myc) are reduced dramatically
during late stage erythroid maturation, coinciding with cell cycle arrest in G 1 phase and
enucleation, suggesting possible roles for c-Myc in either or both of these processes. Here
we demonstrate that ectopic Myc expression affects terminal erythroid maturation in a dose …