Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions
A Lawan, H Shi, F Gatzke, AM Bennett - Cellular and molecular life …, 2013 - Springer
A Lawan, H Shi, F Gatzke, AM Bennett
Cellular and molecular life sciences, 2013•SpringerThe balance of protein phosphorylation is achieved through the actions of a family of protein
serine/threonine kinases called the mitogen-activated protein kinases (MAPKs). The
propagation of MAPK signals is attenuated through the actions of the MAPK phosphatases
(MKPs). The MKPs specifically inactivate the MAPKs by direct dephosphorylation. The
archetypal MKP family member, MKP-1 has garnered much of the attention amongst its ten
other MKP family members. Initially viewed to play a redundant role in the control of MAPK …
serine/threonine kinases called the mitogen-activated protein kinases (MAPKs). The
propagation of MAPK signals is attenuated through the actions of the MAPK phosphatases
(MKPs). The MKPs specifically inactivate the MAPKs by direct dephosphorylation. The
archetypal MKP family member, MKP-1 has garnered much of the attention amongst its ten
other MKP family members. Initially viewed to play a redundant role in the control of MAPK …
Abstract
The balance of protein phosphorylation is achieved through the actions of a family of protein serine/threonine kinases called the mitogen-activated protein kinases (MAPKs). The propagation of MAPK signals is attenuated through the actions of the MAPK phosphatases (MKPs). The MKPs specifically inactivate the MAPKs by direct dephosphorylation. The archetypal MKP family member, MKP-1 has garnered much of the attention amongst its ten other MKP family members. Initially viewed to play a redundant role in the control of MAPK signaling, it is now clear that MKP-1 exerts profound regulatory functions on the immune, metabolic, musculoskeletal and nervous systems. This review focuses on the physiological functions of MKP-1 that have been revealed using mouse genetic approaches. The implications from studies using MKP-1-deficient mice to uncover the role of MKP-1 in disease will be discussed.
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