Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function
Impaired angiogenesis and decreased vascular endothelial growth factor (VEGF)
expression were recently documented in the remnant kidney (RK) model of progressive
renal failure. VEGF (50 μg/kg, twice daily) was administered to RK rats between weeks 4
and 8 after surgery, and rats were euthanized at week 8 for histologic study. During the
administration of VEGF (n= 7) or vehicle (n= 6), systemic BP was comparable in the two
groups. VEGF treatment resulted in improved renal function and lower mortality rates …
expression were recently documented in the remnant kidney (RK) model of progressive
renal failure. VEGF (50 μg/kg, twice daily) was administered to RK rats between weeks 4
and 8 after surgery, and rats were euthanized at week 8 for histologic study. During the
administration of VEGF (n= 7) or vehicle (n= 6), systemic BP was comparable in the two
groups. VEGF treatment resulted in improved renal function and lower mortality rates …
