Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin
M Komuta, B Spee, S Vander Borght, R De Vos… - Hepatology, 2008 - journals.lww.com
Cholangiolocellular carcinoma (CLC), a subtype of cholangiocellular carcinoma (CC), is
thought to originate from the ductules/canals of Hering, where hepatic progenitor cells
(HPCs) are located. We investigated the clinicopathological features of 30 CLCs and their
relationship to HPCs. We evaluated the expression of hepatocytic markers (hepatocyte
paraffin-1, canalicular polyclonal carcinoembryonic antigen, and CD10), biliary/HPC
markers (keratin [K] 7, K19, and neural cell adhesion molecule), the adenosine triphosphate …
thought to originate from the ductules/canals of Hering, where hepatic progenitor cells
(HPCs) are located. We investigated the clinicopathological features of 30 CLCs and their
relationship to HPCs. We evaluated the expression of hepatocytic markers (hepatocyte
paraffin-1, canalicular polyclonal carcinoembryonic antigen, and CD10), biliary/HPC
markers (keratin [K] 7, K19, and neural cell adhesion molecule), the adenosine triphosphate …
