[HTML][HTML] The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes
RL Dusek, S Getsios, F Chen, JK Park… - Journal of Biological …, 2006 - ASBMB
Although a number of cell adhesion proteins have been identified as caspase substrates,
the potential role of differentiation-specific desmosomal cadherins during apoptosis has not
been examined. Here, we demonstrate that UV-induced caspase cleavage of the human
desmoglein 1 cytoplasmic tail results in distinct 17-and 140-kDa products, whereas
metalloproteinase-dependent shedding of the extracellular adhesion domain generates a
75-kDa product. In vitro studies identify caspase-3 as the preferred enzyme that cleaves …
the potential role of differentiation-specific desmosomal cadherins during apoptosis has not
been examined. Here, we demonstrate that UV-induced caspase cleavage of the human
desmoglein 1 cytoplasmic tail results in distinct 17-and 140-kDa products, whereas
metalloproteinase-dependent shedding of the extracellular adhesion domain generates a
75-kDa product. In vitro studies identify caspase-3 as the preferred enzyme that cleaves …