Functional imaging of a large demyelinating lesion
MV Padma, M Adineh, K Pugar, J Mukherjee… - Journal of Clinical …, 2005 - Elsevier
MV Padma, M Adineh, K Pugar, J Mukherjee, M Satter, B Shi, K Dunigan, K Bidwell…
Journal of Clinical Neuroscience, 2005•ElsevierPURPOSE.: To determine the metabolic characterization of a large solitary demyelinating
lesion. METHODS.: Magnetic Resonance Spectroscopy (MRS) and Positron Emission
Tomography (PET) studies with 2-deoxy-2-[F-18] fluoro-d-glucose (FDG), carbon-11-
methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating
lesion. RESULTS.: The demyelinating lesion exhibited a low glucose uptake, prominent
methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an …
lesion. METHODS.: Magnetic Resonance Spectroscopy (MRS) and Positron Emission
Tomography (PET) studies with 2-deoxy-2-[F-18] fluoro-d-glucose (FDG), carbon-11-
methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating
lesion. RESULTS.: The demyelinating lesion exhibited a low glucose uptake, prominent
methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an …
PURPOSE
To determine the metabolic characterization of a large solitary demyelinating lesion.
METHODS
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro-d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating lesion.
RESULTS
The demyelinating lesion exhibited a low glucose uptake, prominent methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an increased choline to creatine (cho/cr) ratio and a decreased N-acetyl-aspartate to creatine (NAA/cr) ratio, which demonstrated a return to near normal ratios on follow-up study.
CONCLUSION
The report summarizes the metabolic characteristics of a demyelinating plaque.
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