Apolipoprotein B100 autoimmunity and atherosclerosis–disease mechanisms and therapeutic potential
J Nilsson, H Björkbacka… - Current opinion in …, 2012 - journals.lww.com
J Nilsson, H Björkbacka, GN Fredrikson
Current opinion in lipidology, 2012•journals.lww.comThese novel findings suggest that aggravation of plaque inflammation may occur as a result
of a local loss of tolerance against LDL in the plaque due to insufficient activity of regulatory
T cells. Restoration of lost tolerance represents an interesting novel approach for treatment
of cardiovascular disease.
of a local loss of tolerance against LDL in the plaque due to insufficient activity of regulatory
T cells. Restoration of lost tolerance represents an interesting novel approach for treatment
of cardiovascular disease.
Summary
These novel findings suggest that aggravation of plaque inflammation may occur as a result of a local loss of tolerance against LDL in the plaque due to insufficient activity of regulatory T cells. Restoration of lost tolerance represents an interesting novel approach for treatment of cardiovascular disease.
Lippincott Williams & Wilkins