The Th17/Treg imbalance in patients with acute coronary syndrome

X Cheng, X Yu, Y Ding, Q Fu, J Xie, T Tang, R Yao… - Clinical …, 2008 - Elsevier
Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets.
Recently, CD4+ CD25+ Foxp3+ regulatory T (Treg) cells and Th17 cells have been
described as two distinct subsets from Th1 and Th2 cells and have the opposite effects on
autoimmunity. Th17/Treg balance controls inflammation and may be important in the
pathogenesis of plaque destabilization and the onset of acute coronary syndrome [ACS,
including unstable angina (UA) and acute myocardial infarction (AMI)]. To assess whether …