[HTML][HTML] Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes
RO Balza, RP Misra - Journal of Biological Chemistry, 2006 - ASBMB
The serum response factor (SRF) is a transcriptional regulator required for mesodermal
development, including heart formation and function. Previous studies have described the
role of SRF in controlling expression of structural genes involved in conferring the myogenic
phenotype. Recent studies by us and others have demonstrated embryonic lethal
cardiovascular phenotypes in SRF-null animals, but have not directly addressed the
mechanistic role of SRF in controlling broad regulatory programs in cardiac cells. In this …
development, including heart formation and function. Previous studies have described the
role of SRF in controlling expression of structural genes involved in conferring the myogenic
phenotype. Recent studies by us and others have demonstrated embryonic lethal
cardiovascular phenotypes in SRF-null animals, but have not directly addressed the
mechanistic role of SRF in controlling broad regulatory programs in cardiac cells. In this …