[HTML][HTML] Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes
MR Barron, NS Belaguli, SX Zhang, M Trinh… - Journal of Biological …, 2005 - ASBMB
We tested the idea that T-box factors direct serum response factor (SRF) gene activity early
in development. Analysis of SRF-LacZ" knock-in" mice showed highly restricted expression
in early embryonic cardiac and skeletal muscle mesoderm and neuroectoderm. Examination
of the SRF gene for regulatory regions by linking the promoter and 5′-flanking sequences,
up to 5.5 kb, failed to target LacZ transgene activity to the heart and the tail pre-somitic
mesenchyme. However, linkage of a minimal SRF promoter with the SRF 3′-untranslated …
in development. Analysis of SRF-LacZ" knock-in" mice showed highly restricted expression
in early embryonic cardiac and skeletal muscle mesoderm and neuroectoderm. Examination
of the SRF gene for regulatory regions by linking the promoter and 5′-flanking sequences,
up to 5.5 kb, failed to target LacZ transgene activity to the heart and the tail pre-somitic
mesenchyme. However, linkage of a minimal SRF promoter with the SRF 3′-untranslated …