Quantitative isolation and in vivo imaging of malaria parasite liver stages
AS Tarun, K Baer, RF Dumpit, S Gray… - International journal for …, 2006 - Elsevier
The liver stages of Plasmodium, the causative agent of malaria, are the least explored forms
in the parasite's life cycle despite their recognition as key vaccine and drug targets. In vivo
experimental access to liver stages of human malaria parasites is practically prohibited and
therefore rodent model malaria parasites have been used for in vivo studies. However, even
in rodent models progress in the analysis of liver stages has been limited, mainly due to their
low abundance and associated difficulties in visualisation and isolation. Here, we present …
in the parasite's life cycle despite their recognition as key vaccine and drug targets. In vivo
experimental access to liver stages of human malaria parasites is practically prohibited and
therefore rodent model malaria parasites have been used for in vivo studies. However, even
in rodent models progress in the analysis of liver stages has been limited, mainly due to their
low abundance and associated difficulties in visualisation and isolation. Here, we present …