[HTML][HTML] Overexpression of H ferritin and up-regulation of iron regulatory protein genes during differentiation of 3T3-L1 pre-adipocytes
M Festa, G Ricciardelli, G Mele, C Pietropaolo… - Journal of Biological …, 2000 - ASBMB
The role of iron-dependent oxidative metabolism in protecting the oxidable substrates
contained in mature adipocytes is still unclear. Because differentiation increases ferritin
formation in several cell types, thereby leading to an accumulation of H-rich isoferritins, we
investigated whether differentiation affects iron metabolism in 3T3-L1 pre-adipocytes. To this
aim, we evaluated the expression of the genes coding for the H and L ferritin subunits and
for cytoplasmic iron regulatory protein (IRP) during the differentiation of 3T3-L1 cells in …
contained in mature adipocytes is still unclear. Because differentiation increases ferritin
formation in several cell types, thereby leading to an accumulation of H-rich isoferritins, we
investigated whether differentiation affects iron metabolism in 3T3-L1 pre-adipocytes. To this
aim, we evaluated the expression of the genes coding for the H and L ferritin subunits and
for cytoplasmic iron regulatory protein (IRP) during the differentiation of 3T3-L1 cells in …