[HTML][HTML] Purification of Cranin, a Laminin Binding Membrane Protein: IDENTITY WITH DYSTROGLYCAN AND REASSESSMENT OF ITS CARBOHYDRATE MOIETIES …
NR Smalheiser, E Kim - Journal of Biological Chemistry, 1995 - ASBMB
Cranin was described in 1987 as a membrane glycoprotein expressed in brain and many
other tissues, which binds laminin with high affinity in a calcium-dependent manner.
Dystrophin-associated glycoprotein (" dystroglycan") is a laminin-binding protein cloned in
1992 whose relation to cranin has remained uncertain. Here we describe the purification of
cranin to homogeneity from sheep brain, show cranin to be a form of dystroglycan, and
localize the N terminus of β-dystroglycan to amino acid residue 654. We find that brain α …
other tissues, which binds laminin with high affinity in a calcium-dependent manner.
Dystrophin-associated glycoprotein (" dystroglycan") is a laminin-binding protein cloned in
1992 whose relation to cranin has remained uncertain. Here we describe the purification of
cranin to homogeneity from sheep brain, show cranin to be a form of dystroglycan, and
localize the N terminus of β-dystroglycan to amino acid residue 654. We find that brain α …
