[HTML][HTML] Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration
Cyclin D1 is an important cell cycle regulator, but in cancer its overexpression also
increases cellular migration mediated by p27 KIP1 stabilization and RhoA inhibition.
Recently, a common polymorphism at the exon 4-intron 4 boundary of the human cyclin D1
gene within a splice donor region was associated with an altered risk of developing cancer.
Altered RNA splicing caused by this polymorphism gives rise to a variant cyclin D1 isoform
termed cyclin D1b, which has the same N terminus as the canonical cyclin D1a isoform but a …
increases cellular migration mediated by p27 KIP1 stabilization and RhoA inhibition.
Recently, a common polymorphism at the exon 4-intron 4 boundary of the human cyclin D1
gene within a splice donor region was associated with an altered risk of developing cancer.
Altered RNA splicing caused by this polymorphism gives rise to a variant cyclin D1 isoform
termed cyclin D1b, which has the same N terminus as the canonical cyclin D1a isoform but a …