[HTML][HTML] Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor α (TNFα)-converting enzyme activity and TNFα secretion …
KA Rozenova, GM Deevska, AA Karakashian… - Journal of Biological …, 2010 - ASBMB
Acid sphingomyelinase (ASMase) has been proposed to mediate lipopolysaccharide (LPS)
signaling in various cell types. This study shows that ASMase is a negative regulator of LPS-
induced tumor necrosis factor α (TNFα) secretion in macrophages. ASMase-deficient
(asm−/−) mice and isolated peritoneal macrophages produce severalfold more TNFα than
their wild-type (asm+/+) counterparts when stimulated with LPS, whereas the addition of
exogenous ceramides or sphingomyelinase reduces the differences. The underlying …
signaling in various cell types. This study shows that ASMase is a negative regulator of LPS-
induced tumor necrosis factor α (TNFα) secretion in macrophages. ASMase-deficient
(asm−/−) mice and isolated peritoneal macrophages produce severalfold more TNFα than
their wild-type (asm+/+) counterparts when stimulated with LPS, whereas the addition of
exogenous ceramides or sphingomyelinase reduces the differences. The underlying …