Plasma sphingomyelin concentration is correlated with the development of atherosclerosis.
It has been found to exist in significantly higher concentrations in aortic plaque. This appears
to have clinical relevance as well as it has been shown to be an independent predictor of
coronary artery disease. Ceramide, the backbone of sphingolipids, is the key component
which affects atherosclerotic changes through its important second-messenger role. This
paper sheds light on some of the current literature supporting the significance of ceramide …