[HTML][HTML] Acid sphingomyelinase deficiency prevents diet-induced hepatic triacylglycerol accumulation and hyperglycemia in mice
GM Deevska, KA Rozenova, NV Giltiay… - Journal of biological …, 2009 - ASBMB
Acid sphingomyelinase plays important roles in ceramide homeostasis, which has been
proposed to be linked to insulin resistance. To test this association in vivo, acid
sphingomyelinase deletion (asm–/–) was transferred to mice lacking the low density
lipoprotein receptor (ldlr–/–), and then offsprings were placed on control or modified
(enriched in saturated fat and cholesterol) diets for 10 weeks. The modified diet caused
hypercholesterolemia in all genotypes; however, in contrast to asm+/+/ldlr–/–, the acid …
proposed to be linked to insulin resistance. To test this association in vivo, acid
sphingomyelinase deletion (asm–/–) was transferred to mice lacking the low density
lipoprotein receptor (ldlr–/–), and then offsprings were placed on control or modified
(enriched in saturated fat and cholesterol) diets for 10 weeks. The modified diet caused
hypercholesterolemia in all genotypes; however, in contrast to asm+/+/ldlr–/–, the acid …