[HTML][HTML] Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila [S]
A Kohyama-Koganeya, T Nabetani, M Miura… - Journal of lipid …, 2011 - ASBMB
Glucosylceramide synthase (GlcT-1) catalyzes the synthesis of glucosylceramide (GlcCer),
the core structure of major glycosphingolipids (GSLs). Obesity is a metabolic disorder
caused by an imbalance between energy uptake and expenditure, resulting in excess stored
body fat. Recent studies have shown that GSL levels are increased in obese rodents and
that pharmacologically reducing GSL levels by inhibiting GlcCer synthesis improves
adipocyte function. However, the molecular mechanism underlying these processes is still …
the core structure of major glycosphingolipids (GSLs). Obesity is a metabolic disorder
caused by an imbalance between energy uptake and expenditure, resulting in excess stored
body fat. Recent studies have shown that GSL levels are increased in obese rodents and
that pharmacologically reducing GSL levels by inhibiting GlcCer synthesis improves
adipocyte function. However, the molecular mechanism underlying these processes is still …