Overweight, insulin resistance and type II diabetes in type I Gaucher disease patients in relation to enzyme replacement therapy
M Langeveld, M De Fost, J Aerts, HP Sauerwein… - Blood Cells, Molecules …, 2008 - Elsevier
Type I Gaucher disease, a lysosomal storage disorder is associated with metabolic
abnormalities such as high resting energy expenditure, low circulating adiponectin and
peripheral insulin resistance. Treatment with enzyme replacement therapy (enzyme therapy)
leads to a decrease in resting energy expenditure, but its influence on weight and risk of
development of type II diabetes is unknown. We studied the BMI, prevalence of overweight,
insulin resistance and type II diabetes in untreated and enzyme therapy treated Gaucher …
abnormalities such as high resting energy expenditure, low circulating adiponectin and
peripheral insulin resistance. Treatment with enzyme replacement therapy (enzyme therapy)
leads to a decrease in resting energy expenditure, but its influence on weight and risk of
development of type II diabetes is unknown. We studied the BMI, prevalence of overweight,
insulin resistance and type II diabetes in untreated and enzyme therapy treated Gaucher …