[HTML][HTML] Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells
R Hyde, K Peyrollier, HS Hundal - Journal of Biological Chemistry, 2002 - ASBMB
SAT1–3 comprise members of the recently cloned family of System A transporters that
mediate the sodium-coupled uptake of short chain neutral amino acids, and their activity is
regulated extensively by stimuli such as insulin, growth factors, and amino acid availability.
In skeletal muscle, insulin stimulates System A activity rapidly by a presently ill-defined
mechanism. Here we demonstrate that insulin induces an increase in the plasma membrane
abundance of SAT2 in a phosphatidylinositol 3-kinase-dependent manner and that this …
mediate the sodium-coupled uptake of short chain neutral amino acids, and their activity is
regulated extensively by stimuli such as insulin, growth factors, and amino acid availability.
In skeletal muscle, insulin stimulates System A activity rapidly by a presently ill-defined
mechanism. Here we demonstrate that insulin induces an increase in the plasma membrane
abundance of SAT2 in a phosphatidylinositol 3-kinase-dependent manner and that this …