The intracellular responses to many distinct extracellular signals involve the direction of
broad-based protein kinases and protein phosphatases to catalyse quite specific protein
phosphorylation/dephosphorylation events. It is now clear that such specificity is often
achieved through subcellular targeting of distinct pools of kinase or phosphatase towards
particular substrates at specific subcellular locations. Given the dynamic nature of protein
phosphorylation reactions, coordinated control of both kinase and phosphatases is often …