High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic …
V Paradis, G Perlemuter, F Bonvoust, D Dargere… - Hepatology, 2001 - Elsevier
Nonalcoholic steatohepatitis (NASH) may progress to liver fibrosis and cirrhosis.
Mechanisms directly involved in the development of fibrosis have been poorly investigated.
Because connective tissue growth factor (CTGF) is an intermediate key molecule involved in
the pathogenesis of fibrosing chronic liver diseases and is potentially induced by
hyperglycemia, the aims of this study were to (1) study the expression of CTGF in vivo both
in human liver biopsy specimens of patients with NASH and in an experimental model of …
Mechanisms directly involved in the development of fibrosis have been poorly investigated.
Because connective tissue growth factor (CTGF) is an intermediate key molecule involved in
the pathogenesis of fibrosing chronic liver diseases and is potentially induced by
hyperglycemia, the aims of this study were to (1) study the expression of CTGF in vivo both
in human liver biopsy specimens of patients with NASH and in an experimental model of …
