Serum and muscle interleukin-15 levels decrease in aging mice: correlation with declines in soluble interleukin-15 receptor alpha expression
LBS Quinn, BG Anderson, L Strait-Bodey… - Experimental …, 2010 - Elsevier
Interleukin-15 (IL-15) is a skeletal muscle-derived cytokine with favorable effects on muscle
mass and body composition. Modulation of IL-15 levels has been suggested as a treatment
for sarcopenia and age-associated increases in adiposity. However, it is unclear whether IL-
15 levels change during aging, as measurement of IL-15 at physiological concentrations in
mice has been technically difficult, and translational regulation of IL-15 is complex.
Moreover, the IL-15 receptor alpha (IL-15Rα) can comprise part of a membrane-associated …
mass and body composition. Modulation of IL-15 levels has been suggested as a treatment
for sarcopenia and age-associated increases in adiposity. However, it is unclear whether IL-
15 levels change during aging, as measurement of IL-15 at physiological concentrations in
mice has been technically difficult, and translational regulation of IL-15 is complex.
Moreover, the IL-15 receptor alpha (IL-15Rα) can comprise part of a membrane-associated …
