Orthotopic aortic transplantation in mice: a new model of allograft arteriosclerosis
C Dambrin, D Calise, MT Pieraggi, JC Thiers… - The Journal of heart and …, 1999 - Elsevier
BACKGROUND: Graft arteriosclerosis is a major cause of death after allotransplantation of
organs such as the heart or the kidney. Aortic allotransplantation in mice is a useful
experimental model to study the mechanisms of this pathology. However, the conventional
heterotopic aortic model is limited by a high morbidity and is technically difficult to perform.
We developed a new simple method for aortic transplantation in mice. METHODS: The
infrarenal aorta from the donor mouse was anastomosed to the recipient's aorta at the same …
organs such as the heart or the kidney. Aortic allotransplantation in mice is a useful
experimental model to study the mechanisms of this pathology. However, the conventional
heterotopic aortic model is limited by a high morbidity and is technically difficult to perform.
We developed a new simple method for aortic transplantation in mice. METHODS: The
infrarenal aorta from the donor mouse was anastomosed to the recipient's aorta at the same …
