Models of cardiac hypertrophy and transition to heart failure
JM Berry, RH Naseem, BA Rothermel, JA Hill - Drug Discovery Today …, 2007 - Elsevier
The prevalence of heart failure is increasing rapidly worldwide, and yet effective treatments
remain elusive. Pathological remodeling of the ventricle–and associated hypertrophic
growth, fibrotic change, cavity dilatation and electrophysiological remodeling–is a significant
contributor to the pathogenesis of this prevalent disorder. As a consequence, there is great
interest in developing new therapies to target pathological remodeling of the heart with the
intent to prevent, arrest, or possibly reverse the otherwise inexorable progression of disease …
remain elusive. Pathological remodeling of the ventricle–and associated hypertrophic
growth, fibrotic change, cavity dilatation and electrophysiological remodeling–is a significant
contributor to the pathogenesis of this prevalent disorder. As a consequence, there is great
interest in developing new therapies to target pathological remodeling of the heart with the
intent to prevent, arrest, or possibly reverse the otherwise inexorable progression of disease …