[HTML][HTML] T-cadherin is a major glycophosphoinositol-anchored protein associated with noncaveolar detergent-insoluble domains of the cardiac sarcolemma
DD Doyle, GE Goings, J Upshaw-Earley, E Page… - Journal of Biological …, 1998 - ASBMB
Sucrose-density flotation analysis of Triton-insoluble membrane domains isolated from
highly purified sheep ventricular sarcolemma revealed the presence of two major 120-and
100-kDa proteins. Both species migrated in two-dimensional isoelectric focussing/SDS gels
with an apparent pI of∼ 4.3, suggesting that they might be related. Microsequence analysis
of peptides derived from the 100-kDa protein yielded amino acid sequences with high
homology to T-cadherin, a truncated cadherin lacking a cytoplasmic domain. The similarity …
highly purified sheep ventricular sarcolemma revealed the presence of two major 120-and
100-kDa proteins. Both species migrated in two-dimensional isoelectric focussing/SDS gels
with an apparent pI of∼ 4.3, suggesting that they might be related. Microsequence analysis
of peptides derived from the 100-kDa protein yielded amino acid sequences with high
homology to T-cadherin, a truncated cadherin lacking a cytoplasmic domain. The similarity …