Liver X receptor modulators: effects on lipid metabolism and potential use in the treatment of atherosclerosis
C Fievet, B Staels - Biochemical pharmacology, 2009 - Elsevier
C Fievet, B Staels
Biochemical pharmacology, 2009•ElsevierLiver X receptors (LXRs) are nuclear receptors that play a crucial role in regulating the
expression of genes involved in lipid metabolism. Ligand activation of LXRs improves
cholesterol homeostasis via multiple coordinated effects, and this function is likely to explain
in part the protective effects of LXR activation on atherosclerosis reported in animal models.
However, LXR activation may also induce undesirable side effects, such as lipogenesis and
hypertriglyceridemia. This review discusses the potential to develop LXR modulators as …
expression of genes involved in lipid metabolism. Ligand activation of LXRs improves
cholesterol homeostasis via multiple coordinated effects, and this function is likely to explain
in part the protective effects of LXR activation on atherosclerosis reported in animal models.
However, LXR activation may also induce undesirable side effects, such as lipogenesis and
hypertriglyceridemia. This review discusses the potential to develop LXR modulators as …
Liver X receptors (LXRs) are nuclear receptors that play a crucial role in regulating the expression of genes involved in lipid metabolism. Ligand activation of LXRs improves cholesterol homeostasis via multiple coordinated effects, and this function is likely to explain in part the protective effects of LXR activation on atherosclerosis reported in animal models. However, LXR activation may also induce undesirable side effects, such as lipogenesis and hypertriglyceridemia. This review discusses the potential to develop LXR modulators as therapeutic agents for atherosclerosis.
Elsevier
