Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation
TA Wilgus, MS Ross, ML Parrett… - Prostaglandins & other lipid …, 2000 - Elsevier
Ultraviolet B (UVB) radiation causes much of the cutaneous damage after both acute and
long-term exposure, and is also the most important etiologic agent in human skin cancer.
UVB exposure initially induces an inflammatory response characterized by edema, dermal
infiltration of leukocytes, sunburn cell formation, as well as the induction of cyclooxygenase-
2 (COX-2) gene expression and subsequent increase in the production and release of
prostaglandins. This process of inflammation induced by UVB exposure has been linked to …
long-term exposure, and is also the most important etiologic agent in human skin cancer.
UVB exposure initially induces an inflammatory response characterized by edema, dermal
infiltration of leukocytes, sunburn cell formation, as well as the induction of cyclooxygenase-
2 (COX-2) gene expression and subsequent increase in the production and release of
prostaglandins. This process of inflammation induced by UVB exposure has been linked to …
