[HTML][HTML] The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-β
SMF Ribeiro, M Poczatek, S Schultz-Cherry… - Journal of Biological …, 1999 - ASBMB
One of the primary points of regulation of transforming growth factor-β (TGF-β) activity is
control of its conversion from the latent precursor to the biologically active form. We have
identified thrombospondin-1 as a major physiological regulator of latent TGF-β activation.
Activation is dependent on the interaction of a specific sequence in thrombospondin-1 (K
412 RFK 415) with the latent TGF-β complex. Platelet thrombospon-din-1 has TGF-β activity
and immunoreactive mature TGF-β associated with it. We now report that the latency …
control of its conversion from the latent precursor to the biologically active form. We have
identified thrombospondin-1 as a major physiological regulator of latent TGF-β activation.
Activation is dependent on the interaction of a specific sequence in thrombospondin-1 (K
412 RFK 415) with the latent TGF-β complex. Platelet thrombospon-din-1 has TGF-β activity
and immunoreactive mature TGF-β associated with it. We now report that the latency …