Activation of the HIF pathway in cancer
PH Maxwell, CW Pugh, PJ Ratcliffe - Current opinion in genetics & …, 2001 - Elsevier
PH Maxwell, CW Pugh, PJ Ratcliffe
Current opinion in genetics & development, 2001•ElsevierThe maintenance of oxygen homeostasis is required both in physiological development and
tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes.
Reliable methods for visualising HIF α subunits have established that HIF activation occurs
in the majority of common cancers. This occurs both by genetic mechanisms and through
microenviromental hypoxia. Activation of the HIF pathway has important effects on patterns
of gene expression in tumours.
tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes.
Reliable methods for visualising HIF α subunits have established that HIF activation occurs
in the majority of common cancers. This occurs both by genetic mechanisms and through
microenviromental hypoxia. Activation of the HIF pathway has important effects on patterns
of gene expression in tumours.
The maintenance of oxygen homeostasis is required both in physiological development and tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes. Reliable methods for visualising HIF α subunits have established that HIF activation occurs in the majority of common cancers. This occurs both by genetic mechanisms and through microenviromental hypoxia. Activation of the HIF pathway has important effects on patterns of gene expression in tumours.
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