Inhibition of vascular endothelial growth factor receptor-1/Wnt/β-catenin crosstalk leads to tumor cell death
Clinical Cancer Research, 2009•AACR
Two genes are considered synthetic lethal if mutation of either alone allows cell viability,
whereas simultaneous mutation leads to cell death. A synthetic lethal screen unveiled the
dependency of Wnt/β-catenin-addicted colorectal cancer cells on vascular endothelial
growth factor receptor-1 kinase activity and suggested a novel therapeutic approach for this
malignancy.(Clin Cancer Res 2009; 15 (24): 7453–5)
whereas simultaneous mutation leads to cell death. A synthetic lethal screen unveiled the
dependency of Wnt/β-catenin-addicted colorectal cancer cells on vascular endothelial
growth factor receptor-1 kinase activity and suggested a novel therapeutic approach for this
malignancy.(Clin Cancer Res 2009; 15 (24): 7453–5)
Abstract
Two genes are considered synthetic lethal if mutation of either alone allows cell viability, whereas simultaneous mutation leads to cell death. A synthetic lethal screen unveiled the dependency of Wnt/β-catenin-addicted colorectal cancer cells on vascular endothelial growth factor receptor-1 kinase activity and suggested a novel therapeutic approach for this malignancy. (Clin Cancer Res 2009;15(24):7453–5)
AACR
