Aquaporin 2 mutations in nephrogenic diabetes insipidus
AJM Loonen, NVAM Knoers, CH van Os… - Seminars in nephrology, 2008 - Elsevier
Water reabsorption in the renal collecting duct is regulated by the antidiuretic hormone
vasopressin (AVP). When the vasopressin V2 receptor, present on the basolateral site of the
renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be
inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-
urine into the interstitium. The essential role of the vasopressin V2 receptor and AQP2 in the
maintenance of body water homeostasis became clear when it was shown that mutations in …
vasopressin (AVP). When the vasopressin V2 receptor, present on the basolateral site of the
renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be
inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-
urine into the interstitium. The essential role of the vasopressin V2 receptor and AQP2 in the
maintenance of body water homeostasis became clear when it was shown that mutations in …