[HTML][HTML] Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation
R Zhou, PM Snyder - Journal of Biological Chemistry, 2005 - ASBMB
Serum and glucocorticoid-regulated kinase (SGK) plays a key role in the regulation of
epithelial Na+ transport. SGK phosphorylates Nedd4-2, an E3 ubiquitin-protein ligase that
targets the epithelial Na+ channel (ENaC) for degradation. Phosphorylation increases Na+
transport by reducing Nedd4-2 binding to ENaC, which increases ENaC expression at the
cell surface. Thus, SGK expression must be tightly controlled to maintain Na+ homeostasis.
This occurs in part by regulation of SGK transcription; a variety of signals including steroid …
epithelial Na+ transport. SGK phosphorylates Nedd4-2, an E3 ubiquitin-protein ligase that
targets the epithelial Na+ channel (ENaC) for degradation. Phosphorylation increases Na+
transport by reducing Nedd4-2 binding to ENaC, which increases ENaC expression at the
cell surface. Thus, SGK expression must be tightly controlled to maintain Na+ homeostasis.
This occurs in part by regulation of SGK transcription; a variety of signals including steroid …