Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis
J Scholz, V Lukacs-Kornek, DR Engel… - Journal of the …, 2008 - journals.lww.com
The role of renal dendritic cells (DCs) in glomerulonephritis is unknown. This question was
addressed in nephrotoxic nephritis, a murine model of human necrotizing
glomerulonephritis, which is dependent on CD4+ Th1 cells and macrophages. DCs in
nephritic kidneys showed signs of activation, accumulated in the tubulo-interstitium, and
infiltrated the periglomerular space surrounding inflamed glomeruli. In ex vivo coculture
experiments with antigen-specific CD4+ T cells, DCs stimulated the secretion of IL-10, which …
addressed in nephrotoxic nephritis, a murine model of human necrotizing
glomerulonephritis, which is dependent on CD4+ Th1 cells and macrophages. DCs in
nephritic kidneys showed signs of activation, accumulated in the tubulo-interstitium, and
infiltrated the periglomerular space surrounding inflamed glomeruli. In ex vivo coculture
experiments with antigen-specific CD4+ T cells, DCs stimulated the secretion of IL-10, which …