[HTML][HTML] The Role of Decay-accelerating Factor as a Receptor for Helicobacter pylori and a Mediator of Gastric Inflammation*♦
DP O'Brien, DA Israel, U Krishna… - Journal of Biological …, 2006 - ASBMB
Persistent gastritis induced by Helicobacter pylori is the strongest known risk factor for peptic
ulcer disease and distal gastric adenocarcinoma, a process for which adherence of H. pylori
to gastric epithelial cells is critical. Decay-accelerating factor (DAF), a protein that protects
epithelial cells from complement-mediated lysis, also functions as a receptor for several
microbial pathogens. In this study, we investigated whether H. pylori utilizes DAF as a
receptor and the role of DAF within H. pylori-infected gastric mucosa. In vitro studies showed …
ulcer disease and distal gastric adenocarcinoma, a process for which adherence of H. pylori
to gastric epithelial cells is critical. Decay-accelerating factor (DAF), a protein that protects
epithelial cells from complement-mediated lysis, also functions as a receptor for several
microbial pathogens. In this study, we investigated whether H. pylori utilizes DAF as a
receptor and the role of DAF within H. pylori-infected gastric mucosa. In vitro studies showed …