Different mechanisms of intrinsic pain inhibition in early and late inflammation
H Machelska, JK Schopohl, SA Mousa, D Labuz… - Journal of …, 2003 - Elsevier
Neuroimmune interactions control pain through activation of opioid receptors on sensory
nerves by immune-derived opioid peptides. Here we evaluate mechanisms of intrinsic pain
inhibition at different stages of Freund's adjuvant-induced inflammation of the rat paw. We
use immunohistochemistry and paw pressure testing. Our data show that in early (6 h)
inflammation leukocyte-derived β-endorphin, met-enkephalin and dynorphin A activate
peripheral μ-, δ-and κ-receptors to inhibit nociception. In addition, central opioid …
nerves by immune-derived opioid peptides. Here we evaluate mechanisms of intrinsic pain
inhibition at different stages of Freund's adjuvant-induced inflammation of the rat paw. We
use immunohistochemistry and paw pressure testing. Our data show that in early (6 h)
inflammation leukocyte-derived β-endorphin, met-enkephalin and dynorphin A activate
peripheral μ-, δ-and κ-receptors to inhibit nociception. In addition, central opioid …
