[HTML][HTML] Morphine activates opioid receptors without causing their rapid internalization
DE Keith, SR Murray, PA Zaki, PC Chu… - Journal of Biological …, 1996 - ASBMB
We have examined the endocytic trafficking of epitope-tagged δ and µ opioid receptors
expressed in human embryonic kidney (HEK) 293 cells. These receptors are activated by
peptide agonists (enkephalins) as well as by the alkaloid agonist drugs etorphine and
morphine. Enkephalins and etorphine cause opioid receptors to internalize rapidly (t1/2~ 6
min) by a mechanism similar to that utilized by a number of other classes of receptor, as
indicated by localization of internalized opioid receptors in transferrin-containing …
expressed in human embryonic kidney (HEK) 293 cells. These receptors are activated by
peptide agonists (enkephalins) as well as by the alkaloid agonist drugs etorphine and
morphine. Enkephalins and etorphine cause opioid receptors to internalize rapidly (t1/2~ 6
min) by a mechanism similar to that utilized by a number of other classes of receptor, as
indicated by localization of internalized opioid receptors in transferrin-containing …
