Background Neuronal degeneration and dopamine loss in the preclinical phase of
Parkinson disease may produce subtle complaints before clinically recognizable symptoms
emerge. Objective To examine whether subjective complaints of stiffness, slowness, tremors,
or postural imbalance in persons without clinical signs of parkinsonism are related to an
increased risk of future Parkinson disease. Design Population-based cohort study. We
recorded subjective complaints of stiffness, slowness of movement, tremors, falling, or a …