Oxysterol regulation of steroidogenic acute regulatory protein gene expression: Structural specificity and transcriptional and posttranscriptional actions
LK Christenson, JM McAllister, KO Martin… - Journal of Biological …, 1998 - ASBMB
Oxysterols exert a major influence over cellular cholesterol homeostasis. We examined the
effects of oxysterols on the expression of steroidogenic acute regulatory protein (StAR),
which increases the delivery of cholesterol to sterol-metabolizing P450s in the mitochondria.
22 (R)-hydroxycholesterol (22 (R)-OHC), 25-OHC, and 27-OHC each increased
steroidogenic factor-1 (SF-1)-mediated StAR gene transactivation by∼ 2-fold in CV-1 cells.
In contrast, cholesterol, progesterone, and the 27-OHC metabolites, 27-OHC-5β-3-one and …
effects of oxysterols on the expression of steroidogenic acute regulatory protein (StAR),
which increases the delivery of cholesterol to sterol-metabolizing P450s in the mitochondria.
22 (R)-hydroxycholesterol (22 (R)-OHC), 25-OHC, and 27-OHC each increased
steroidogenic factor-1 (SF-1)-mediated StAR gene transactivation by∼ 2-fold in CV-1 cells.
In contrast, cholesterol, progesterone, and the 27-OHC metabolites, 27-OHC-5β-3-one and …