Cyclooxygenase isozymes and their gene structures and expression
T Tanabe, N Tohnai - Prostaglandins & other lipid mediators, 2002 - Elsevier
The cyclooxygenase (COX, prostaglandin endoperoxide synthase) is a key enzyme in
prostaglandin biosynthesis. Two isoforms of COX, COX-1 and COX-2, have been identified
by molecular biological methods. The amino acid sequence homology between COX-1 and
COX-2 is about 60% for the human enzymes. COX-1 is constitutively expressed in most
tissues and cells in animal species. The COX-1 promoter region lacks a canonical TATA or
CAAT box and is GC-rich. These features are consistent with those of a housekeeping gene …
prostaglandin biosynthesis. Two isoforms of COX, COX-1 and COX-2, have been identified
by molecular biological methods. The amino acid sequence homology between COX-1 and
COX-2 is about 60% for the human enzymes. COX-1 is constitutively expressed in most
tissues and cells in animal species. The COX-1 promoter region lacks a canonical TATA or
CAAT box and is GC-rich. These features are consistent with those of a housekeeping gene …
