[HTML][HTML] Palmitate activates the NF-κB transcription factor and induces IL-6 and TNFα expression in 3T3-L1 adipocytes
KM Ajuwon, ME Spurlock - The Journal of nutrition, 2005 - Elsevier
Fatty acids and their metabolites regulate gene expression and immunological pathways.
Furthermore, obese individuals frequently have increased circulating fatty acid
concentrations, and localized inflammation in adipose tissue may facilitate the systemic
inflammation associated with the insulin resistance of obesity. Although palmitate induces
inflammation (ie, activates proinflammatory pathways) in myotubes, the effects of fatty acids
on inflammatory processes in adipocytes have not been established. Therefore, we …
Furthermore, obese individuals frequently have increased circulating fatty acid
concentrations, and localized inflammation in adipose tissue may facilitate the systemic
inflammation associated with the insulin resistance of obesity. Although palmitate induces
inflammation (ie, activates proinflammatory pathways) in myotubes, the effects of fatty acids
on inflammatory processes in adipocytes have not been established. Therefore, we …