Antibodies to polynucleotides: distribution in human serums
D Koffler, RI Carr, V Agnello, T Fiezi, HG Kunkel - Science, 1969 - science.org
D Koffler, RI Carr, V Agnello, T Fiezi, HG Kunkel
Science, 1969•science.orgHemagglutination procedures were used to determine the distribution of antibodies to native
DNA, single-stranded DNA, and double-stranded RNA. Antibodies to all three
polynucleotides were found in a high percentage of the serums of patients with systemic
lupus erythematosus. Antibodies to native DNA occurred almost exclusively in serums of
patients in the active stages of systemic lupus erythematosus, whereas antibodies to single-
stranded DNA were observed in the serums of patients with several diseases and of some …
DNA, single-stranded DNA, and double-stranded RNA. Antibodies to all three
polynucleotides were found in a high percentage of the serums of patients with systemic
lupus erythematosus. Antibodies to native DNA occurred almost exclusively in serums of
patients in the active stages of systemic lupus erythematosus, whereas antibodies to single-
stranded DNA were observed in the serums of patients with several diseases and of some …
Hemagglutination procedures were used to determine the distribution of antibodies to native DNA, single-stranded DNA, and double-stranded RNA. Antibodies to all three polynucleotides were found in a high percentage of the serums of patients with systemic lupus erythematosus. Antibodies to native DNA occurred almost exclusively in serums of patients in the active stages of systemic lupus erythematosus, whereas antibodies to single-stranded DNA were observed in the serums of patients with several diseases and of some normal individuals.
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