Gliotoxin-mediated apoptosis of activated human hepatic stellate cells
YO Kweon, YH Paik, B Schnabl, T Qian… - Journal of …, 2003 - Elsevier
Background: Activated hepatic stellate cells (HSCs) play a central role in liver fibrogenesis,
and apoptosis of activated HSCs might be essential to clear HSCs from injured liver.
Gliotoxin induces apoptosis of activated human and rat HSCs by an unknown mechanism.
Aim: This study investigated the role of reactive oxygen species (ROS) and membrane
permeability transition (MPT) in gliotoxin-induced apoptosis of activated human HSCs.
Methods: Primary and immortalized human HSCs were analyzed using confocal microscopy …
and apoptosis of activated HSCs might be essential to clear HSCs from injured liver.
Gliotoxin induces apoptosis of activated human and rat HSCs by an unknown mechanism.
Aim: This study investigated the role of reactive oxygen species (ROS) and membrane
permeability transition (MPT) in gliotoxin-induced apoptosis of activated human HSCs.
Methods: Primary and immortalized human HSCs were analyzed using confocal microscopy …
