Monoclonal antibody to vascular endothelial-cadherin is a potent inhibitor of angiogenesis, tumor growth, and metastasis
F Liao, Y Li, W O'Connor, L Zanetta, R Bassi… - Cancer research, 2000 - AACR
F Liao, Y Li, W O'Connor, L Zanetta, R Bassi, A Santiago, J Overholser, A Hooper, P Mignatti…
Cancer research, 2000•AACRVascular endothelial-cadherin (VE-cad) is an endothelial cell-specific adhesion molecule
that is crucial for proper assembly of vascular tubes. Here we show that a monoclonal
antibody (BV13) directed to the extracellular region of VE-cad inhibits formation of adherens
junctions and capillary-like structures by endothelial cells and blocks angiogenesis in the
mouse cornea and in Matrigel plugs in vivo. Systemic administration of BV13 markedly
decreases the growth of sc Lewis lung or human A431 epidermoid tumors and strongly …
that is crucial for proper assembly of vascular tubes. Here we show that a monoclonal
antibody (BV13) directed to the extracellular region of VE-cad inhibits formation of adherens
junctions and capillary-like structures by endothelial cells and blocks angiogenesis in the
mouse cornea and in Matrigel plugs in vivo. Systemic administration of BV13 markedly
decreases the growth of sc Lewis lung or human A431 epidermoid tumors and strongly …
Abstract
Vascular endothelial-cadherin (VE-cad) is an endothelial cell-specific adhesion molecule that is crucial for proper assembly of vascular tubes. Here we show that a monoclonal antibody (BV13) directed to the extracellular region of VE-cad inhibits formation of adherens junctions and capillary-like structures by endothelial cells and blocks angiogenesis in the mouse cornea and in Matrigel plugs in vivo. Systemic administration of BV13 markedly decreases the growth of s.c. Lewis lung or human A431 epidermoid tumors and strongly suppresses the growth of Lewis lung metastases. These data demonstrate that VE-cad is essential for postnatal angiogenesis and thus validate VE-cad as a novel target for antiangiogenesis agents.
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